Phytochemical, pharmacological and pharmacokinetics effects of rosmarinic acid. It displays general antioxidant and antiinflammatory effects, and may protect against various forms of cancers. Solvent extraction and purification of rosmarinic acid from supercritical fluid extraction fractionation waste. It is commonly found in species of the boraginaceae and the subfamily nepetoideae of the lamiaceae. Rosmarinic acid ra, an ester of caffeic acid and 3,4dihydrophenyllactic acid figure 1 fig. Rosmarinic acid is a constituent of the plant as well as a cosmetic ingredient. By the supramolecular complex which was formed from flavocommelin and perilla leaf extract as initial materials, the supernatant containing rosmarinic acid was isolated. The invention relates to an extraction separation method of rosmarinic acid in salvia castabea diels f. Uidbim0429320 and norte2020programa operacional regional do norte norte010145feder000012. Abstract rosmarinic acid is a fundamental compound of rosmarinus officinalis. The main components of the caffeic acid derivatives fraction of leaves of mentha piperita l. Pdf bioactivity and potential health benefits of rosmarinic acid. The present invention is directed to a new rosmarinic acid phospholipidecomplex product containing rosmarinic acid and the phospholipide in a molar ratio of 1.
The above chart shows that rosmarinic acid was able to inhibit the formation of ages by 97. Rosmarinic acid and its methyl ester as antimicrobial. Chemically, rosmarinic acid is a caffeic acid ester of 33,4dihydroxyphenyllactic acid natural occurrences. Inthepresentwork,wereexaminedthee ects of summer savory extracts and thier rosmarinic acid rich.
Ra has numerous biological and pharmacological activities. The invention is further directed to a process for producing the same and to pharmaceutical preparations containing the same. While rosmarinus officinalis rosemaryderived ingredients are reported to have a number of functions, the most common. Safety assessment of rosmarinus officinalis rosemary. Validated hplcpda method for rosmarinic acid quantification in rosemary article pdf available in latin american journal of pharmacy 3010. Rosmarinic acid extract with potent biological activities was successfully isolated by supramolecular technique and solvent extraction from perilla leaves. Influence of nitrogen nutrition on growth and accumulation. In this work, the intrinsic prooxidant generation of h2o2. Rosmarinic acid is a phenolic compound and ester of caffeic acid, which is. Rosemary, whose major caffeoylderived and diterpenoid ingredients are rosmarinic acid, carnosol, and carnosic acid, is an important source of natural antioxidants and is being recognized increasingly as a useful preservative, protectant, and even as a potential medicinal agent. Four compounds were detected as responsible for the major part of the antimicrobial activity of h.
It may help fight herpes simplex virus as well as improve heart and lung function. It is a redorange powder that is slightly soluble in water, but well soluble is most organic solvents. Rosmarinic acid the active ingredient from rosemary. Although it is mostly know for its ability to improve mood and memory, it has other benefits, too. However, previous studies of rosmarinic acid in cell models have yielded controversial results. Evaluation of the virucidal effects of rosmarinic acid.
Ampactivated kinase ampk is an energy sensor, its activation increases glucose uptake in skeletal muscle and ampk activators have been viewed as a targeted approach in combating insulin. Rosmarinic acid is an ester of caffeic acid and 3, 4dihydroxyphenyllactic acid. Raisabundantinseveralmedicinal plants of the lamiaceae family, such as rosemary rosmarinus officinalis l. Recent studies on rosmarinic acid and its biological ncbi. Analysis of the virucidal effects of rosmarinic acid ra on ev71 infection. However, it is also found in species of other higher plant families and in some fern and hornwort species. First was to establish high rosmarinic acid line of in vitro sprout. Rosmarinic acid, a new snake venom phospholipase a2 inhibitor from cordia verbenacea boraginaceae. Additionally, it can be absorbed through the skin when in an ethanol base. Rosa is most commonly found in species of the boraginaceae and the subfamily nepetoideae of the lamiaceae. Skeletal muscle is a major insulintarget tissue and plays an important role in glucose homeostasis. Clovamide and rosmarinic acid induce neuroprotective effects in in vitro models of neuronal death. Rosmarinic acid is a natural watersoluble antioxidant, with a variety of biological activity, widely used in food, medicine, and cosmetics. These fractions led to pure compounds via bioguided fractionations see section 2.
The aim of this study in healthy humans was to determine the absorption, metabolism, and urinary excretion of rosmarinic acid ra after a single intake of perilla extract pe. Bioproduction and optimization of rosmarinic acid production in solenostemon of high yielding clone via encapsulation. Rosmarinic acid ra, an ester of caffeic acid and 3,4dihydrophenyllactic acid figure 1, is a naturally occurring phenylpropanoid that is commonly found in species of the boraginaceae family, the subfamily nepetoideae of the lamiaceae family, and in lower plants such as ferns and hornworts petersen and simmonds, 2003. The antioxidant capacity as trolox equivalent antioxidant capacity teac and total phenolic contents, based on folinciocalteu reagent, in different ocimum species were quantitated. Overview rosmarinic acid complex a very good defense against inflammatory ailments like cardiovascular disease, arthritis, and asthma. Rosmarinic acid extract for antioxidant, antiallergic, and. Among its numerous biologic functions, rosmarinic acid is known supporting a healthy eosiniphil response and healthy b and t. Structurally speaking rosmarinic acid is a dimer of caffeic acid and 3,4dihydroxyphenyllactic acid, bound by an ester linkage and is known as a phenylpropanoid. Rosmarinic acid content of fe and ae the concentration of rosmarinic acid in ae and fe was determined by hplc as previously described, with some modifications wang et al. Recent studies on rosmarinic acid and its biological and.
Degradation study of carnosic acid, carnosol, rosmarinic. Highperformance liquid chromatography hplc was used to identify and quantify rosmarinic acid, the. Antioxidant activity, total phenolics, and rosmarinic acid. Lemon balm melissa officinalis, balm, common balm, or balm mint, is a perennial herbaceous plant in the mint family lamiaceae and native to southcentral europe, the mediterranean basin, iran, and central asia, but now naturalized in the americas and elsewhere it grows to a maximum height of 70150 cm 2859 in. Search results for rosmarinic acid at sigmaaldrich. Rosmarinic acid is one of the polyphenolic substances contained in culinary herbs such as perilla perilla. Despite the fact that several peaks appear in the tea chromatogram, the rosmarinic acid peak is always the major peak and appears with t r 7. Oregano and other medicinal mint species have antioxidant properties which are now known to be due in large part to rosmarinic acid ra a compound with proven medicinal value and wellcharacterized physiological functions. Rosmarinic acid supplement health benefits, dosage, side. The leaves have a mild lemon scent similar to mint. Improvement effect of rosmarinic acid on serum testosterone. Rosmarinic acid is a fundamental compound of rosmarinus officinalis. Typical chromatograms for rosmarinic acid and melissa officinalis tea sample are shown in figures 2 and 3, respectively. Studies on jamu and the medicinal resources in indonesia.
Recent advances in the analysis of rosmarinic acid from herbs in. Quantification of chlorogenic acid, rosmarinic acid, and. In this work, the intrinsic prooxidant generation of h 2 o 2 and free radicals by the action of peroxidase and antioxidant consumption of h 2 o 2 and free radicals properties of rosmarinic acid are characterized. Sources of rosmarinic acid rosmarinic acid can be extracted from rosemary rosmarinus officinalis, a woody, perennial herb native to the mediterranean region which is a commonly used. Molecules free fulltext rosmarinic acid, a rosemary. Rosmarinic acid protects human dopaminergic neuronal cells against hydrogen peroxideinduced apoptosis. Rosmarinic acid is a phenolic compound and ester of caffeic acid, which is naturally occurring in several plants of the lamiaceae family, including rosemary rosmarinus officinalis, from which it was originally isolated, sage salvia officinalis and spanish sage salvia lavandulifolia, basil ocimum tenuiflorum, oregano origanum vulgare, marjoram origanum majorana, and. Influence of rosmarinic acid and salvia officinalis.
Understanding the stability of these components and their mode of interaction in mixtures is important if they are. Rosmarinic acid is an ester of caffeic acid and 3,4dihydroxyphenyllactic acid. Their structures were established by spectroscopic analysis mono and bidimensional nmr, ms and direct comparison with published data 14, 15 as rosmarinic acid ra, 0. Rosmarinic acid accumulation is shown in hornworts, in the fern family blechnaceae and in species of several.
Cn103044253a extraction separation method of rosmarinic. In addition, its melanogenic prooxidant activity is characterized as it acts as a substrate of. Rosmarinic acid has a number of interesting biological. Pdf phytochemical, pharmacological and pharmacokinetics. N2 a thinlayer chromatographic tlcdensitometric method was used for the parallel quantification of rosmarinic acid ra and caffeic acid ca in crude extracts of salvia species family lamiaceae, obtained by ultrasonic extraction with 60% methanol. Rosmarinic acid is potent flavonoid with powerful antioxidant and antiinflammatory properties. Rosmarinic acid, an ester of caffeic acid and 3,4dihydroxyphenyllactic acid, is a specialized plant metabolite that occurs in rather high quantities mainly in species of the subfamily nepetoideae of the lamiaceae and the boraginaceae, but also. Rosmarinic acid, derived from rosemary a member of the mint. Rosmarinic acid is a plantbased compound found in a wide variety of spices, but most well known for being the active ingredient in rosemary and perilla oil. The effect of rosmarinic acid on immunological and. Rosmarinic acid figure 1c, an ester of caffeic acid and 3, 4dihydroxyphenyllactic acid, is commonly found in species of the boraginaceae, lamiaceae, and in some ferns and hornworts petersen, simmonds, 2003.
Carnosic acid had stronger inhibition at lower dosages, however when reaching concentrations over 100 lgmg that rate of inhibition dropped. Rosmarinic acid ra is an ester of caffeic acid and 3,4dihydroxyphenyllactic acid which is one of the most frequently occurring caffeic acid esters in the plant kingdom besides chlorogenic acid. Dunal, in principles and practice of phytotherapy second edition, 20. Rosmarinic acid was first isolated and characterized in 1958 by the italian chemists m. The method comprises the following steps that salvia castabea diels f. Phytochemical is produced when a herb reacts on environmental. Rosmarinic acid and related metabolites springerlink. Quantitative hplc analysis of rosmarinic acid in extracts. Pdf solvent extraction and purification of rosmarinic. Rosmarinic acid pharmaceutical and clinical aspects. Rosmarinic acid ra, an ester of caffeic acid and 3. Research article rosmarinic acidrich extracts of summer.